Ontology highlight
ABSTRACT:
SUBMITTER: Leidecker O
PROVIDER: S-EPMC5113755 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Leidecker Orsolya O Bonfiglio Juan José JJ Colby Thomas T Zhang Qi Q Atanassov Ilian I Zaja Roko R Palazzo Luca L Stockum Anna A Ahel Ivan I Matic Ivan I
Nature chemical biology 20161010 12
ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage. ...[more]