Ontology highlight
ABSTRACT:
SUBMITTER: Eising S
PROVIDER: S-EPMC5113785 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20160908 40
Bioorthogonal reactions are widely used for the chemical modification of biomolecules. The application of vinylboronic acids (VBAs) as non-strained, synthetically accessible and water-soluble reaction partners in a bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction with 3,6-dipyridyl-s-tetrazines is described. Depending on the substituents, VBA derivatives give second-order rate constants up to 27 m(-1) s(-1) in aqueous environments at room temperature, which is suitable for bio ...[more]