Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC5113834 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Li Mufeng M Toombes Gilman E S GE Silberberg Shai D SD Swartz Kenton J KJ
Nature neuroscience 20150921 11
The selectivity of ion channels is fundamental for their roles in electrical and chemical signaling and in ion homeostasis. Although most ion channels exhibit stable ion selectivity, the prevailing view of purinergic P2X receptor channels, transient receptor potential V1 (TRPV1) channels and acid-sensing ion channels (ASICs) is that their ion conduction pores dilate upon prolonged activation. We investigated this mechanism in P2X receptors and found that the hallmark shift in equilibrium potenti ...[more]