Ontology highlight
ABSTRACT:
SUBMITTER: Bernier LP
PROVIDER: S-EPMC5980614 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Bernier Louis-Philippe LP Ase Ariel R AR Séguéla Philippe P
British journal of pharmacology 20170817 12
Chronic pain is a highly prevalent debilitating condition for which treatment options remain limited for many patients. Ionotropic ATP signalling through excitatory and calcium-permeable P2X receptor channels is now rightfully considered as a critical player in pathological pain generation and maintenance; therefore, their selective targeting represents a therapeutic opportunity with promising yet untapped potential. Recent advances in the structural, functional and pharmacological characterizat ...[more]