Ontology highlight
ABSTRACT:
SUBMITTER: Keck ZY
PROVIDER: S-EPMC5115987 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Keck Zhen-Yong ZY Wang Yong Y Lau Patrick P Lund Garry G Rangarajan Sneha S Fauvelle Catherine C Liao Grant C GC Holtsberg Frederick W FW Warfield Kelly L KL Aman M Javad MJ Pierce Brian G BG Fuerst Thomas R TR Bailey Justin R JR Baumert Thomas F TF Mariuzza Roy A RA Kneteman Norman M NM Foung Steven K H SK
Hepatology (Baltimore, Md.) 20161028 6
Direct-acting antivirals (DAAs) have led to a high cure rate in treated patients with chronic hepatitis C virus (HCV) infection, but this still leaves a large number of treatment failures secondary to the emergence of resistance-associated variants (RAVs). To increase the barrier to resistance, a complementary strategy is to use neutralizing human monoclonal antibodies (HMAbs) to prevent acute infection. However, earlier efforts with the selected antibodies led to RAVs in animal and clinical stu ...[more]