Ontology highlight
ABSTRACT:
SUBMITTER: Foxley MA
PROVIDER: S-EPMC5115998 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Foxley Melissa A MA Friedline Anthony W AW Jensen Jessica M JM Nimmo Susan L SL Scull Erin M EM King Jarrod B JB Strange Stoffel S Xiao Min T MT Smith Benjamin E BE Thomas Iii Kieth J KJ Glatzhofer Daniel T DT Cichewicz Robert H RH Rice Charles V CV
The Journal of antibiotics 20160518 12
β-Lactam antibiotics kill Staphylococcus aureus bacteria by inhibiting the function of cell wall penicillin-binding proteins (PBPs) 1 and 3. However, β-lactams are ineffective against PBP2a, used by methicillin-resistant S. aureus (MRSA) to perform essential cell wall crosslinking functions. PBP2a requires teichoic acid to properly locate and orient the enzyme, and thus MRSA is susceptible to antibiotics that prevent teichoic acid synthesis in the bacterial cytoplasm. As an alternative, we have ...[more]