Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC5117136 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
The journal of physical chemistry letters 20160928 19
Ribozymes employ diverse catalytic strategies in their self-cleavage mechanisms, including the use of divalent metal ions. This work explores the effects of Mg<sup>2+</sup> ions in the active site of the glmS ribozyme-GlcN6P cofactor complex using computational methods. Deleterious and potentially beneficial effects of an active site Mg<sup>2+</sup> ion on the self-cleavage reaction were identified. The presence of a Mg<sup>2+</sup> ion near the scissile phosphate oxygen atoms at the cleavage si ...[more]