Ontology highlight
ABSTRACT:
SUBMITTER: Green YS
PROVIDER: S-EPMC5117148 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Green Yangsook Song YS Kwon Sunjong S Mimoto Mizuho S MS Xie Yuanyuan Y Christian Jan L JL
Development (Cambridge, England) 20160915 21
In Xenopus laevis, bone morphogenetic proteins (Bmps) induce expression of the transcription factor Gata2 during gastrulation, and Gata2 is required in both ectodermal and mesodermal cells to enable mesoderm to commit to a hematopoietic fate. Here, we identify tril as a Gata2 target gene that is required in both ectoderm and mesoderm for primitive hematopoiesis to occur. Tril is a transmembrane protein that functions as a co-receptor for Toll-like receptors to mediate innate immune responses in ...[more]