Factors associated with recurrence and survival length following relapse in patients with neuroblastoma.

ABSTRACT:

Background

Despite therapeutic advances, survival following relapse for neuroblastoma patients remains poor. We investigated clinical and biological factors associated with length of progression-free and overall survival following relapse in UK neuroblastoma patients.

Methods

All cases of relapsed neuroblastoma, diagnosed during 1990-2010, were identified from four Paediatric Oncology principal treatment centres. Kaplan-Meier and Cox regression analyses were used to calculate post-relapse overall survival (PROS), post-relapse progression-free survival (PRPFS) between relapse and further progression, and to investigate influencing factors.

Results

One hundred eighty-nine cases were identified from case notes, 159 (84.0%) high risk and 17 (9.0%), unresectable, MYCN non-

SUBMITTER: Basta NO 

PROVIDER: S-EPMC5117794 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature