Ontology highlight
ABSTRACT:
SUBMITTER: Andersen-Nissen E
PROVIDER: S-EPMC5117823 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Andersen-Nissen Erica E Chang Joanne T JT Thomas Katherine K KK Adams Devin D Celum Connie C Sanchez Jorge J Coombs Robert W RW McElrath M Juliana MJ Baeten Jared M JM
Sexually transmitted diseases 20161201 12
<h4>Background</h4>Herpes simplex virus type-2 (HSV-2) may heighten immune activation and increase human immunodeficiency virus 1 (HIV-1) replication, resulting in greater infectivity and faster HIV-1 disease progression. An 18-week randomized, placebo-controlled crossover trial of 500 mg valacyclovir twice daily in 20 antiretroviral-naive women coinfected with HSV-2 and HIV-1 was conducted and HSV-2 suppression was found to significantly reduce both HSV-2 and HIV-1 viral loads both systemically ...[more]