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ABSTRACT:
SUBMITTER: Baeten JM
PROVIDER: S-EPMC2665183 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Baeten Jared M JM Strick Lara B LB Lucchetti Aldo A Whittington William L H WL Sanchez Jorge J Coombs Robert W RW Magaret Amalia A Wald Anna A Corey Lawrence L Celum Connie C
The Journal of infectious diseases 20081201 12
A randomized cross-over trial of herpes simplex virus type 2 (HSV-2)-suppressive therapy (valacyclovir, 500 mg twice daily, or placebo for 8 weeks, a 2-week washout period, then the alternative therapy for 8 weeks) was conducted among 20 Peruvian women coinfected with HSV-2 and human immunodeficiency virus type 1 (HIV-1) who were not on antiretroviral therapy. Plasma samples (obtained weekly) and endocervical swab specimens (obtained thrice weekly) were collected for HIV-1 RNA polymerase chain r ...[more]