Ontology highlight
ABSTRACT:
SUBMITTER: Basuli F
PROVIDER: S-EPMC5118155 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Basuli Falguni F Zhang Xiang X Jagoda Elaine M EM Choyke Peter L PL Swenson Rolf E RE
Nuclear medicine and biology 20160830 12
Fluorine-18 labeled fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester has been successfully synthesized in an unprecedented way by flowing an acetonitrile solution of its quaternary ammonium salt precursor (N,N,N-trimethyl-5-((2,3,5,6-tetrafluorophenoxy)carbonyl)pyridin-2-aminium trifluoromethanesulfonate, 1) through an anion exchange cartridge. The fluorination reaction proceeded at room temperature without azeotropic drying of the fluoride. Over 75% conversion was observed with 10mg of prec ...[more]