Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx.
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SUBMITTER: Garsen M
PROVIDER: S-EPMC5118481 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx.
Garsen Marjolein M Lenoir Olivia O Rops Angelique L W M M AL Dijkman Henry B HB Willemsen Brigith B van Kuppevelt Toin H TH Rabelink Ton J TJ Berden Jo H M JH Tharaux Pierre-Louis PL van der Vlag Johan J
Journal of the American Society of Nephrology : JASN 20160329 12
Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Endothelin receptor antagonists have emerged as a novel treatment for DN, but the mechanisms underlying the protective effect remain unknown. We previously showed that both heparanase and endothelin-1 are essential for the development of DN. Here, we further investigated the role of these proteins in DN, and demonstrated that endothelin-1 activates podocytes to release heparanase. Furthermore, conditioned podocyte cultur ...[more]
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