Ontology highlight
ABSTRACT:
SUBMITTER: Gomez IG
PROVIDER: S-EPMC5118488 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Gomez Ivan G IG Roach Allie M AM Nakagawa Naoki N Amatucci Aldo A Johnson Bryce G BG Dunn Kadeshia K Kelly Mark C MC Karaca Gamze G Zheng Timothy S TS Szak Suzanne S Peppiatt-Wildman Claire M CM Burkly Linda C LC Duffield Jeremy S JS
Journal of the American Society of Nephrology : JASN 20160329 12
The identification of the cellular origins of myofibroblasts has led to the discovery of novel pathways that potentially drive myofibroblast perpetuation in disease. Here, we further investigated the role of innate immune signaling pathways in this process. In mice, renal injury-induced activation of pericytes, which are myofibroblast precursors attached to endothelial cells, led to upregulated expression of TNF receptor superfamily member 12a, also known as fibroblast growth factor-inducible 14 ...[more]