Ontology highlight
ABSTRACT:
SUBMITTER: Doerner JL
PROVIDER: S-EPMC4504782 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Doerner Jessica L JL Wen Jing J Xia Yumin Y Paz Karin Blecher KB Schairer David D Wu Lan L Chalmers Samantha A SA Izmirly Peter P Michaelson Jennifer S JS Burkly Linda C LC Friedman Adam J AJ Putterman Chaim C
The Journal of investigative dermatology 20150331 8
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK, TNFSF12) and its sole receptor Fn14, belonging to the TNF ligand and receptor superfamilies respectively, are involved in cell survival and cytokine production. The role of TWEAK/Fn14 interactions in the pathogenesis of cutaneous lupus has not been explored. TWEAK treatment of murine PAM212 keratinocytes stimulated the secretion of RANTES via Fn14 and promoted apoptosis. Parthenolide, but not wortmanin or the MAPK inhibitor PD980 ...[more]