Ontology highlight
ABSTRACT:
SUBMITTER: Koselny K
PROVIDER: S-EPMC5118990 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Koselny Kristy K Green Julianne J DiDone Louis L Halterman Justin P JP Fothergill Annette W AW Wiederhold Nathan P NP Patterson Thomas F TF Cushion Melanie T MT Rappelye Chad C Wellington Melanie M Krysan Damian J DJ
Antimicrobial agents and chemotherapy 20161121 12
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we describe the characterization of the spectrum of in vitro activity and in vivo activity of AR-12, a celecoxib derivative which has been tested in a phase I clinical trial as an anticancer agent. AR-12 inhibits fungal acetyl coenzyme A (acetyl-CoA) syn ...[more]