Ontology highlight
ABSTRACT:
SUBMITTER: Abdulrahman BA
PROVIDER: S-EPMC5730578 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Abdulrahman Basant A BA Abdelaziz Dalia D Thapa Simrika S Lu Li L Jain Shubha S Gilch Sabine S Proniuk Stefan S Zukiwski Alexander A Schatzl Hermann M HM
Scientific reports 20171214 1
Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP<sup>C</sup>) into the pathologic isoform PrP<sup>Sc</sup> is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that demonstrated preclinical activity against several microbial diseases. Recently, AR-12 has been shown to facilitate clearance of misfolded proteins. The latter proposes AR-12 to be a p ...[more]