A Single Nucleotide Change in the Promoter mutp Enhances Fluoride Resistance of Streptococcus mutans.
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ABSTRACT:
SUBMITTER: Liao Y
PROVIDER: S-EPMC5119038 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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A Single Nucleotide Change in the Promoter mutp Enhances Fluoride Resistance of Streptococcus mutans.
Liao Ying Y Brandt Bernd W BW Zhang Min M Li Jiyao J Crielaard Wim W van Loveren Cor C Deng Dong Mei DM
Antimicrobial agents and chemotherapy 20161121 12
Previously, we identified a single nucleotide mutation in the promoter (mutp) of the fluoride antiporter-coding genes in a naturally fluoride-resistant Streptococcus mutans strain. Here, we studied the role of this mutation in a defined genetic background. The results confirmed that this mutation alone confers fluoride resistance on S. mutans, as shown by growth and lactic acid production assays. This resistance was explained by constitutively higher mutp promoter activity and upregulation of th ...[more]
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