Ontology highlight
ABSTRACT:
SUBMITTER: Pholwat S
PROVIDER: S-EPMC5119041 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Pholwat Suporn S Stroup Suzanne S Heysell Scott S Ogarkov Oleg O Zhdanova Svetlana S Ramakrishnan Girija G Houpt Eric E
Antimicrobial agents and chemotherapy 20161121 12
We studied the significance of particular eis mutations on Mycobacterium tuberculosis drug resistance using a specialized transduction strategy. Recombinant strains harboring eis promoter mutations C14T, C12T, and G10A exhibited kanamycin resistance with MICs of 40, 10, and 20 μg/ml, respectively, while recombinant strains harboring C14G and C15G mutations were kanamycin susceptible (MIC, 2.5 to 5 μg/ml). Each of the eis mutants tested remained amikacin susceptible (MIC, 0.5 to 4 μg/ml). The ide ...[more]