Ontology highlight
ABSTRACT:
SUBMITTER: Garzan A
PROVIDER: S-EPMC5154685 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20161122 23
A two-drug combination therapy where one drug targets an offending cell and the other targets a resistance mechanism to the first drug is a time-tested, yet underexploited approach to combat or prevent drug resistance. By high-throughput screening, we identified a sulfonamide scaffold that served as a pharmacophore to generate inhibitors of Mycobacterium tuberculosis acetyltransferase Eis, whose upregulation causes resistance to the aminoglycoside (AG) antibiotic kanamycin A (KAN) in Mycobacteri ...[more]