Immunologic Consequences of Hypoxia during Critical Illness.
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ABSTRACT:
SUBMITTER: Kiers HD
PROVIDER: S-EPMC5119461 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Immunologic Consequences of Hypoxia during Critical Illness.
Kiers Harmke D HD Scheffer Gert-Jan GJ van der Hoeven Johannes G JG Eltzschig Holger K HK Pickkers Peter P Kox Matthijs M
Anesthesiology 20160701 1
Hypoxia and immunity are highly intertwined at clinical, cellular, and molecular levels. The prevention of tissue hypoxia and modulation of systemic inflammation are cornerstones of daily practice in the intensive care unit. Potentially, immunologic effects of hypoxia may contribute to outcome and represent possible therapeutic targets. Hypoxia and activation of downstream signaling pathways result in enhanced innate immune responses, aimed to augment pathogen clearance. On the other hand, hypox ...[more]
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