Dataset Information

The Association of DRD2 with Insight Problem Solving.

ABSTRACT: Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. Several lines of evidence suggest that genes involved in dopamine (DA) transmission might be potential candidates. The present study explored for the first time the association of dopamine D2 receptor gene (DRD2) with insight problem solving. Fifteen single-nucleotide polymorphisms (SNPs) covering DRD2 were genotyped in 425 unrelated healthy Chinese undergraduates, and were further tested for association with insight problem solving. Both single SNP and haplotype analysis revealed several associations of DRD2 SNPs and haplotypes with insight problem solving. In conclusion, the present study provides the first evidence for the involvement of DRD2 in insight problem solving, future studies are necessary to validate these findings.

SUBMITTER: Zhang S

PROVIDER: S-EPMC5121534 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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The Association of DRD2 with Insight Problem Solving.

Zhang Shun S Zhang Jinghuan J

Frontiers in psychology 20161124

Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. Several lines of evidence suggest that genes involved in dopamine (DA) transmission might be potential candidates. The present study explored for the first time the association of dopamine D2 receptor gene (DRD2) with insight problem solving. Fifteen single-nucleotide polymorphisms (SNPs) covering DRD2< ...[more]

PMID: 27933030

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Project description:BackgroundCognitive insight phenomenon lies at the core of numerous discoveries. Behavioral research indicates four salient features of insightful problem solving: (i) mental impasse, followed by (ii) restructuring of the problem representation, which leads to (iii) a deeper understanding of the problem, and finally culminates in (iv) an "Aha!" feeling of suddenness and obviousness of the solution. However, until now no efforts have been made to investigate the neural mechanisms of these constituent features of insight in a unified framework.Methodology/principal findingsIn an electroencephalographic study using verbal remote associate problems, we identified neural correlates of these four features of insightful problem solving. Hints were provided for unsolved problems or after mental impasse. Subjective ratings of the restructuring process and the feeling of suddenness were obtained on trial-by-trial basis. A negative correlation was found between these two ratings indicating that sudden insightful solutions, where restructuring is a key feature, involve automatic, subconscious recombination of information. Electroencephalogram signals were analyzed in the space x time x frequency domain with a nonparametric cluster randomization test. First, we found strong gamma band responses at parieto-occipital regions which we interpreted as (i) an adjustment of selective attention (leading to a mental impasse or to a correct solution depending on the gamma band power level) and (ii) encoding and retrieval processes for the emergence of spontaneous new solutions. Secondly, we observed an increased upper alpha band response in right temporal regions (suggesting active suppression of weakly activated solution relevant information) for initially unsuccessful trials that after hint presentation led to a correct solution. Finally, for trials with high restructuring, decreased alpha power (suggesting greater cortical excitation) was observed in right prefrontal area.Conclusions/significanceOur results provide a first account of cognitive insight by dissociating its constituent components and potential neural correlates.

Project description:Numerous studies of insight problem solving are focused on both the control and storage systems of working memory. We obtained contradictory data about how working memory systems are involved in insight problem solving process. We argue that measuring the dynamics of the control system and storage systems through the course of problem solving can provide a more refined view on the processes involved, as a whole, and explain the existing controversies. We theorize that specific insight mechanisms require varying working memory capacities at different stages of the problem solving process. Our study employed a dual task paradigm to track the dynamics of working memory systems load during problem solving by measuring the reaction time in a secondary probe-task during different stages of problem solving. We varied the modality (verbal, visual) and the complexity of the probe-task during insight and non-insight problem solving. The results indicated that the dynamics of working memory load in insight problems differs from those in non-insight problems. Our first experiment shows that the complexity of the probe-task affects overall probe-task reaction times in both insight and non-insight problem solving. Our second experiment demonstrates that the solution of a non-insight problem is primarily associated with the working memory control system, while insight problems rely on relevant storage systems. Our results confirm that insight process requires access to various systems of working memory throughout the solution. We found that working memory load in non-insight problems increases from stage to stage due to allocation of the attentional control resources to interim calculations. The nature of the dynamics of working memory load in insight problems remains debatable. We claim that insight problem solving demands working memory storage during the entire problem solving process and that control system plays an important role just prior to the solution.

Project description:In this paper we argue that a synthesis of findings across the various sub-areas of research in complex problem solving and consequently progress in theory building is hampered by an insufficient differentiation of complexity and difficulty. In the proposed framework of person, task, and situation (PTS), complexity is conceptualized as a quality that is determined by the cognitive demands that the characteristics of the task and the situation impose. Difficulty represents the quantifiable level of a person's success in dealing with such demands. We use the well-documented "semantic effect" as an exemplar for testing some of the conceptual assumptions derived from the PTS framework. We demonstrate how a differentiation between complexity and difficulty can help take beyond a potentially too narrowly defined psychometric perspective and subsequently gain a better understanding of the cognitive mechanisms behind this effect. In an empirical study a total of 240 university students were randomly allocated to one of four conditions. The four conditions resulted from contrasting the semanticity level of the variable labels used in the CPS system (high vs. low) and two instruction conditions for how to explore the CPS system's causal structure (starting with the assumption that all relationships between variables existed vs. starting with the assumption that none of the relationships existed). The variation in the instruction aimed at inducing knowledge acquisition processes of either (1) systematic elimination of presumptions, or (2) systematic compilation of a mental representation of the causal structure underpinning the system. Results indicate that (a) it is more complex to adopt a "blank slate" perspective under high semanticity as it requires processes of inhibiting prior assumptions, and (b) it seems more difficult to employ a systematic heuristic when testing against presumptions. In combination, situational characteristics, such as the semanticity of variable labels, have the potential to trigger qualitatively different tasks. Failing to differentiate between 'task' and 'situation' as independent sources of complexity and treating complexity and difficulty synonymously threaten the validity of performance scores obtained in CPS research.

Dataset Information

The Association of DRD2 with Insight Problem Solving.

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The Association of <i>DRD2</i> with Insight Problem Solving.

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