Ontology highlight
ABSTRACT:
SUBMITTER: Kong M
PROVIDER: S-EPMC5123691 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Kong Muwen M Liu Lili L Chen Xuejing X Driscoll Katherine I KI Mao Peng P Böhm Stefanie S Kad Neil M NM Watkins Simon C SC Bernstein Kara A KA Wyrick John J JJ Min Jung-Hyun JH Van Houten Bennett B
Molecular cell 20161006 2
Nucleotide excision repair (NER) is an evolutionarily conserved mechanism that processes helix-destabilizing and/or -distorting DNA lesions, such as UV-induced photoproducts. Here, we investigate the dynamic protein-DNA interactions during the damage recognition step using single-molecule fluorescence microscopy. Quantum dot-labeled Rad4-Rad23 (yeast XPC-RAD23B ortholog) forms non-motile complexes or conducts a one-dimensional search via either random diffusion or constrained motion. Atomic forc ...[more]