Ontology highlight
ABSTRACT:
SUBMITTER: Luchetti G
PROVIDER: S-EPMC5123864 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Luchetti Giovanni G Sircar Ria R Kong Jennifer H JH Nachtergaele Sigrid S Sagner Andreas A Byrne Eamon Fx EF Covey Douglas F DF Siebold Christian C Rohatgi Rajat R
eLife 20161005
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling by directly activating Smoothened (SMO), an orphan GPCR that transmits the Hh signal across the membrane in all animals. Unlike many GPCRs, which are regulated by cholesterol through their heptahelic ...[more]