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Adjuvant therapies in advanced hepatocellular carcinoma: moving forward from the STORM.

ABSTRACT: Like other previous treatments and approaches, sorafenib, an antiangiogenic drug, failed to show any benefit in the adjuvant setting for hepatocellular carcinoma in a large clinical trial. We discuss reasons and implications of these negative results and the implications for clinical practice and future research.ClinicalTrials.gov: NCT00692770 . Registered 5 June 2008. This study has been completed.

SUBMITTER: Bouattour M

PROVIDER: S-EPMC5124225 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Adjuvant therapies in advanced hepatocellular carcinoma: moving forward from the STORM.

Bouattour Mohamed M Soubrane Olivier O de Gramont Armand A Faivre Sandrine S

Trials 20161125 1

Like other previous treatments and approaches, sorafenib, an antiangiogenic drug, failed to show any benefit in the adjuvant setting for hepatocellular carcinoma in a large clinical trial. We discuss reasons and implications of these negative results and the implications for clinical practice and future research.<h4>Trial registration</h4>ClinicalTrials.gov: NCT00692770 . Registered 5 June 2008. This study has been completed. ...[more]

PMID: 27887632

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Emerging therapies in advanced hepatocellular carcinoma.

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Adjuvant sorafenib in hepatocellular carcinoma: A cautionary comment of STORM trial.

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