Ontology highlight
ABSTRACT:
SUBMITTER: Dou Y
PROVIDER: S-EPMC5125100 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Dou Yongchao Y Cha Diana J DJ Franklin Jeffrey L JL Higginbotham James N JN Jeppesen Dennis K DK Weaver Alissa M AM Prasad Nripesh N Levy Shawn S Coffey Robert J RJ Patton James G JG Zhang Bing B
Scientific reports 20161128
Recent studies have shown that circular RNAs (circRNAs) are abundant, widely expressed in mammals, and can display cell-type specific expression. However, how production of circRNAs is regulated and their precise biological function remains largely unknown. To study how circRNAs might be regulated during colorectal cancer progression, we used three isogenic colon cancer cell lines that differ only in KRAS mutation status. Cellular RNAs from the parental DLD-1 cells that contain both wild-type an ...[more]