Ontology highlight
ABSTRACT:
SUBMITTER: Demory Beckler M
PROVIDER: S-EPMC3567858 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Demory Beckler Michelle M Higginbotham James N JN Franklin Jeffrey L JL Ham Amy-Joan AJ Halvey Patrick J PJ Imasuen Imade E IE Whitwell Corbin C Li Ming M Liebler Daniel C DC Coffey Robert J RJ
Molecular & cellular proteomics : MCP 20121115 2
Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of mutant KRAS are less understood. We recently reported that exosomes isolated from mutant KRAS-expressing colon cancer cells enhanced the invasiveness of recipient cells relative to exosomes purified from wild-type KRAS-expressing cells, leading us to hypothesize mutant KRAS might affect neighboring and distant cells b ...[more]