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Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.

ABSTRACT: Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database.

SUBMITTER: Rho JR

PROVIDER: S-EPMC5125438 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.

Rho Jung-Rae JR Subramaniam Gurusamy G Choi Hyukjae H Kim Eun-Hee EH Ng Sok Peng SP Yoganathan K K Ng Siewbee S Buss Antony D AD Butler Mark S MS Gerwick William H WH

Organic letters 20150227 6

Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database. ...[more]

PMID: 25723256

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