Ontology highlight
ABSTRACT:
SUBMITTER: Gao R
PROVIDER: S-EPMC5125707 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Gao Rongsui R Hu Yongfei Y Li Zhencui Z Sun Jian J Wang Qingjing Q Lin Jingxia J Ye Huiyan H Liu Fei F Srinivas Swaminath S Li Defeng D Zhu Baoli B Liu Ya-Hong YH Tian Guo-Bao GB Feng Youjun Y
PLoS pathogens 20161128 11
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomics of two new mcr-1-harbouring plasmids isolated from the human gut microbiota, highlighting the divers ...[more]