Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC6347640 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhang Huimin H Hou Mengyun M Xu Yongchang Y Srinivas Swaminath S Huang Man M Liu Lizhang L Feng Youjun Y
Communications biology 20190125
Colistin is the last-resort antibiotic against lethal infections with multidrug-resistant bacterial pathogens. A rainbow coalition of mobile colistin resistance (<i>mcr</i>) genes raises global health concerns. Here, we describe the action and mechanism of colistin resistance imparted by MCR-4, a recently-identified member from the broader MCR family. We found that MCR-4 originates from the silenced variant of <i>Shewanella frigidimarina</i> via progressive evolution and forms a phylogenetically ...[more]