Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5127278 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Wang Lili L Brooks Angela N AN Fan Jean J Wan Youzhong Y Gambe Rutendo R Li Shuqiang S Hergert Sarah S Yin Shanye S Freeman Samuel S SS Levin Joshua Z JZ Fan Lin L Seiler Michael M Buonamici Silvia S Smith Peter G PG Chau Kevin F KF Cibulskis Carrie L CL Zhang Wandi W Rassenti Laura Z LZ Ghia Emanuela M EM Kipps Thomas J TJ Fernandes Stacey S Bloch Donald B DB Kotliar Dylan D Landau Dan A DA Shukla Sachet A SA Aster Jon C JC Reed Robin R DeLuca David S DS Brown Jennifer R JR Neuberg Donna D Getz Gad G Livak Kenneth J KJ Meyerson Matthew M MM Kharchenko Peter V PV Wu Catherine J CJ
Cancer cell 20161103 5
Mutations in SF3B1, which encodes a spliceosome component, are associated with poor outcome in chronic lymphocytic leukemia (CLL), but how these contribute to CLL progression remains poorly understood. We undertook a transcriptomic characterization of primary human CLL cells to identify transcripts and pathways affected by SF3B1 mutation. Splicing alterations, identified in the analysis of bulk cells, were confirmed in single SF3B1-mutated CLL cells and also found in cell lines ectopically expre ...[more]