Unknown

Dataset Information

0

SF3B1 mutation predicts unfavorable treatment-free survival in Chinese chronic lymphocytic leukemia patients.


ABSTRACT: Background:Splicing factor 3b subunit 1 (SF3B1), a splicing factor modulating RNA alternative splicing, is frequently mutated in multiple hematological malignancies including myelodysplastic syndromes and chronic lymphocytic leukemia (CLL). The clinical impact of SF3B1 mutation on CLL remains controversial especially for patients of Asian descent. Methods:We retrospectively analyzed the frequency of SF3B1 mutation by Sanger sequencing in 399 newly diagnosed Chinese CLL patients. Results:SF3B1 mutation was detected in 5.5% (22/399) of the studied cohort with 59.1% of them being c.A2098G (p.K700E). SF3B1 mutation was common in patients with unmutated immunoglobulin heavy chain variable region gene, positive CD38 and positive ZAP-70. Survival analysis showed that SF3B1 mutation was associated with short treatment-free survival (TFS), but not overall survival (OS). We then developed 2 new risk models, named CLL-IPI-S and CLL-PI, according to the SF3B1 mutation status and CLL-international prognostic index (CLL-IPI); CLL-PI showed greater power to predict TFS than CLL-IPI in Chinese CLL patients. Conclusions:Our data suggest a low incidence and adverse clinical significance of SF3B1 mutation in newly diagnosed Chinese CLL patients.

SUBMITTER: Miao Y 

PROVIDER: S-EPMC6526254 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

<i>SF3B1</i> mutation predicts unfavorable treatment-free survival in Chinese chronic lymphocytic leukemia patients.

Miao Yi Y   Zou Yi-Xin YX   Gu Dan-Ling DL   Zhu Hong-Cheng HC   Zhu Hua-Yuan HY   Wang Li L   Liang Jin-Hua JH   Xia Yi Y   Wu Jia-Zhu JZ   Shao Chun-Lin CL   Fan Lei L   Zhang Zhen Z   Xu Wei W   Li Jian-Yong JY  

Annals of translational medicine 20190401 8


<h4>Background</h4>Splicing factor 3b subunit 1 (<i>SF3B1</i>), a splicing factor modulating RNA alternative splicing, is frequently mutated in multiple hematological malignancies including myelodysplastic syndromes and chronic lymphocytic leukemia (CLL). The clinical impact of <i>SF3B1</i> mutation on CLL remains controversial especially for patients of Asian descent.<h4>Methods</h4>We retrospectively analyzed the frequency of <i>SF3B1</i> mutation by Sanger sequencing in 399 newly diagnosed Ch  ...[more]

Similar Datasets

| S-EPMC5127278 | biostudies-literature
| S-EPMC3650490 | biostudies-literature
| S-EPMC5642526 | biostudies-literature
| S-EPMC10415613 | biostudies-literature
| S-EPMC2117767 | biostudies-literature
| S-EPMC7080807 | biostudies-literature
| S-EPMC3685413 | biostudies-literature
| S-EPMC6415995 | biostudies-literature
| S-EPMC2435687 | biostudies-literature
| S-EPMC6425375 | biostudies-literature