Ontology highlight
ABSTRACT:
SUBMITTER: He H
PROVIDER: S-EPMC5127583 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
He Hongzhi H Ye An A Kim Hana H Kim Joomyeong J
PloS one 20161129 11
Peg3 (Paternally Expressed Gene 3) is an imprinted gene that encodes a zinc finger DNA-binding protein. Peg3 itself is localized in the middle of a KRAB-A (Kruppel-Associated Box) zinc finger gene cluster. The amino acid sequence encoded by its exon 7 also shows sequence similarity to that of KRAB-A, suggesting Peg3 as a KRAB-containing zinc finger gene. As predicted, the PEG3 protein was co-immunoprecipitated with KAP1, a co-repressor that interacts with KRAB-A. A series of follow-up experiment ...[more]