Ontology highlight
ABSTRACT:
SUBMITTER: Fujisaka S
PROVIDER: S-EPMC5127688 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Fujisaka Shiho S Ussar Siegfried S Clish Clary C Devkota Suzanne S Dreyfuss Jonathan M JM Sakaguchi Masaji M Soto Marion M Konishi Masahiro M Softic Samir S Altindis Emrah E Li Ning N Gerber Georg G Bry Lynn L Kahn C Ronald CR
The Journal of clinical investigation 20161024 12
Interactions of diet, gut microbiota, and host genetics play important roles in the development of obesity and insulin resistance. Here, we have investigated the molecular links between gut microbiota, insulin resistance, and glucose metabolism in 3 inbred mouse strains with differing susceptibilities to metabolic syndrome using diet and antibiotic treatment. Antibiotic treatment altered intestinal microbiota, decreased tissue inflammation, improved insulin signaling in basal and stimulated stat ...[more]