Ontology highlight
ABSTRACT:
SUBMITTER: Hewarathna A
PROVIDER: S-EPMC5127730 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Hewarathna Asha A Dremina Elena E Schöneich Christian C
Biochimica et biophysica acta. Proteins and proteomics 20160914 1
An interaction of Bcl-2 with SERCA had been documented in vitro using the SERCA1a isoform isolated from rat skeletal muscle [Dremina, E. S., Sharov, V. S., Kumar, K., Azidi, A., Michaelis, E. K., Schöneich, C. (2004) Biochem. J. 383 (361-370)]. Here, we demonstrate the interaction of Bcl-2 with the SERCA3b isoform both in vitro and in cell culture. In vitro, the interaction of Bcl-2 with SERCA3b was studied using Bcl-2∆21, a truncated form of human Bcl-2, and microsomes isolated from SERCA3b-ove ...[more]