TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling.
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ABSTRACT:
SUBMITTER: Zheng H
PROVIDER: S-EPMC5128793 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling.
Zheng Hao H Yang Yuan Y Han Jun J Jiang Wei-Hua WH Chen Cheng C Wang Meng-Chao MC Gao Rong R Li Shuai S Tian Tao T Wang Jian J Ma Li-Jun LJ Ren Hao H Zhou Wei-Ping WP
Scientific reports 20161130
Transmembrane p24 trafficking protein 3(TMED3) is a metastatic suppressor in colon cancer, but its function in the progression of hepatocellular carcinoma (HCC) is unknown. Here, we report that TMED3 was up-regulated in HCC and portal vein tumor thrombus. TMED3 up-regulation in HCC was significantly correlated with aggressive characteristics and predicted poor prognosis in HCC patients. TMED3 overexpression in HCC cell lines promoted cell migration and invasion. In contrast, TMED3 knockdown supp ...[more]
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