Postinjury Inflammation and Organ Dysfunction.
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ABSTRACT:
SUBMITTER: Sauaia A
PROVIDER: S-EPMC5129870 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Postinjury Inflammation and Organ Dysfunction.
Sauaia Angela A Moore Frederick A FA Moore Ernest E EE
Critical care clinics 20170101 1
The development of organ dysfunction (OD) is related to the intensity and balance between trauma-induced simultaneous, opposite inflammatory responses. Early proinflammation via innate immune system activation may cause early OD, whereas antiinflammation, via inhibition of the adaptive immune system and apoptosis, may induce immunoparalysis, impaired healing, infections, and late OD. Patients discharged with low-level OD may develop the persistent inflammation-immunosuppression catabolism syndro ...[more]
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