Ontology highlight
ABSTRACT:
SUBMITTER: Coleman DJ
PROVIDER: S-EPMC5130036 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Coleman Daniel J DJ Van Hook Kathryn K King Carly J CJ Schwartzman Jacob J Lisac Robert R Urrutia Joshua J Sehrawat Archana A Woodward Josha J Wang Nicholas J NJ Gulati Roman R Thomas George V GV Beer Tomasz M TM Gleave Martin M Korkola James E JE Gao Lina L Heiser Laura M LM Alumkal Joshi J JJ
Oncotarget 20160601 26
Prostate cancer is the most commonly diagnosed and second-most lethal cancer among men in the United States. The vast majority of prostate cancer deaths are due to castration-resistant prostate cancer (CRPC) - the lethal form of the disease that has progressed despite therapies that interfere with activation of androgen receptor (AR) signaling. One emergent resistance mechanism to medical castration is synthesis of intratumoral androgens that activate the AR. This insight led to the development ...[more]