Ontology highlight
ABSTRACT:
SUBMITTER: Meharena HS
PROVIDER: S-EPMC5130182 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Meharena Hiruy S HS Fan Xiaorui X Ahuja Lalima G LG Keshwani Malik M MM McClendon Christopher L CL Chen Angela M AM Adams Joseph A JA Taylor Susan S SS
PLoS biology 20161130 11
Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions that regulate the active state mechanics are not well understood. Here, using cAMP-dependent protein kinase as a representative model coupled with biochemical, biophysical, and computational techniques, ...[more]