Ontology highlight
ABSTRACT:
SUBMITTER: De Bacco F
PROVIDER: S-EPMC5130292 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
De Bacco Francesca F D'Ambrosio Antonio A Casanova Elena E Orzan Francesca F Neggia Roberta R Albano Raffaella R Verginelli Federica F Cominelli Manuela M Poliani Pietro L PL Luraghi Paolo P Reato Gigliola G Pellegatta Serena S Finocchiaro Gaetano G Perera Timothy T Garibaldi Elisabetta E Gabriele Pietro P Comoglio Paolo M PM Boccaccio Carla C
EMBO molecular medicine 20160502 5
Glioblastoma (GBM) contains stem-like cells (GSCs) known to be resistant to ionizing radiation and thus responsible for therapeutic failure and rapidly lethal tumor recurrence. It is known that GSC radioresistance relies on efficient activation of the DNA damage response, but the mechanisms linking this response with the stem status are still unclear. Here, we show that the MET receptor kinase, a functional marker of GSCs, is specifically expressed in a subset of radioresistant GSCs and overexpr ...[more]