Ontology highlight
ABSTRACT:
SUBMITTER: Alam SG
PROVIDER: S-EPMC5131312 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Alam Samer G SG Zhang Qiao Q Prasad Nripesh N Li Yuan Y Chamala Srikar S Kuchibhotla Ram R Kc Birendra B Aggarwal Varun V Shrestha Shristi S Jones Angela L AL Levy Shawn E SE Roux Kyle J KJ Nickerson Jeffrey A JA Lele Tanmay P TP
Scientific reports 20161201
Mechanical integration of the nucleus with the extracellular matrix (ECM) is established by linkage between the cytoskeleton and the nucleus. This integration is hypothesized to mediate sensing of ECM rigidity, but parsing the function of nucleus-cytoskeleton linkage from other mechanisms has remained a central challenge. Here we took advantage of the fact that the LINC (linker of nucleoskeleton and cytoskeleton) complex is a known molecular linker of the nucleus to the cytoskeleton, and asked h ...[more]