Ontology highlight
ABSTRACT:
SUBMITTER: Guo WH
PROVIDER: S-EPMC1386800 | biostudies-other | 2006 Mar
REPOSITORIES: biostudies-other
Guo Wei-hui WH Frey Margo T MT Burnham Nancy A NA Wang Yu-li YL
Biophysical journal 20051230 6
The ability of cells to form tissues represents one of the most fundamental issues in biology. However, it is unclear what triggers cells to adhere to one another in tissues and to migrate once a piece of tissue is planted on culture surfaces. Using substrates of identical chemical composition but different flexibility, we show that this process is controlled by substrate rigidity: on stiff substrates, cells migrate away from one another and spread on surfaces, whereas on soft substrates they me ...[more]