Ontology highlight
ABSTRACT:
SUBMITTER: Isik M
PROVIDER: S-EPMC5131338 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Isik Meltem M Blackwell T Keith TK Berezikov Eugene E
Scientific reports 20161201
Diverse stresses and aging alter expression levels of microRNAs, suggesting a role for these posttranscriptional regulators of gene expression in stress modulation and longevity. Earlier studies demonstrated a central role for the miR-34 family in promoting cell cycle arrest and cell death following stress in human cells. However, the biological significance of this response was unclear. Here we show that in C. elegans mir-34 upregulation is necessary for developmental arrest, correct morphogene ...[more]