Ontology highlight
ABSTRACT:
SUBMITTER: Enchev RI
PROVIDER: S-EPMC5131867 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Enchev Radoslav I RI Schulman Brenda A BA Peter Matthias M
Nature reviews. Molecular cell biology 20150101 1
NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin-RING ligases. Many non-cullin neddylation targets have been proposed in recent years. However, overexpression of exogenous NEDD8 can trigger NEDD8 conjugation through the ubiquitylation machinery, which makes validating potential NEDD8 targets challenging. Here, we re-evaluate studies of non-cullin targets of NEDD8 in light ...[more]