Ontology highlight
ABSTRACT:
SUBMITTER: Kandil S
PROVIDER: S-EPMC5131913 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kandil Sahar S Balzarini Jan J Rat Stephanie S Brancale Andrea A Westwell Andrew D AD McGuigan Christopher C
Bioorganic & medicinal chemistry letters 20161027 23
Nucleosides represent a major chemotherapeutic class for treating cancer, however their limitations in terms of cellular uptake, nucleoside kinase-mediated activation and catabolism are well-documented. The monophosphate pro-nucleotides known as ProTides represents a powerful strategy for bypassing the dependence on active transport and nucleoside kinase-mediated activation. Herein, we report the structural tuning of BVdU ProTides. Forty six phosphoramidates were prepared and biologically evalua ...[more]