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Asymmetric Induction by a Nitrogen ¹⁴ N/¹⁵ N Isotopomer in Conjunction with Asymmetric Autocatalysis.

ABSTRACT: Chirality arising from isotope substitution, especially with atoms heavier than the hydrogen isotopes, is usually not considered a source of chirality in a chemical reaction. An N² ,N² ,N³ ,N³ -tetramethyl-2,3-butanediamine containing nitrogen (¹⁴ N/¹⁵ N) isotope chirality was synthesized and it was revealed that this isotopically chiral diamine compound acts as a chiral initiator for asymmetric autocatalysis.

SUBMITTER: Matsumoto A

PROVIDER: S-EPMC5132014 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Asymmetric Induction by a Nitrogen 14 N/15 N Isotopomer in Conjunction with Asymmetric Autocatalysis.

Matsumoto Arimasa A Ozaki Hanae H Harada Shunya S Tada Kyohei K Ayugase Tomohiro T Ozawa Hitomi H Kawasaki Tsuneomi T Soai Kenso K

Angewandte Chemie (International ed. in English) 20161018 49

Chirality arising from isotope substitution, especially with atoms heavier than the hydrogen isotopes, is usually not considered a source of chirality in a chemical reaction. An N2 ,N2 ,N3 ,N3 -tetramethyl-2,3-butanediamine containing nitrogen (14 N/15 N) isotope chirality was synthesized and it was revealed that this isotopically chiral diamine compound acts as a chiral initiator for asymmetric autocatalysis. ...[more]

PMID: 27754589

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