Ontology highlight
ABSTRACT:
SUBMITTER: Perens EA
PROVIDER: S-EPMC5132343 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Perens Elliot A EA Garavito-Aguilar Zayra V ZV Guio-Vega Gina P GP Peña Karen T KT Schindler Yocheved L YL Yelon Deborah D
eLife 20161102
Proper organogenesis depends upon defining the precise dimensions of organ progenitor territories. Kidney progenitors originate within the intermediate mesoderm (IM), but the pathways that set the boundaries of the IM are poorly understood. Here, we show that the bHLH transcription factor Hand2 limits the size of the embryonic kidney by restricting IM dimensions. The IM is expanded in zebrafish <i>hand2</i> mutants and is diminished when <i>hand2</i> is overexpressed. Within the posterior mesode ...[more]