Ontology highlight
ABSTRACT:
SUBMITTER: Green JB
PROVIDER: S-EPMC23035 | biostudies-literature | 1997 Aug
REPOSITORIES: biostudies-literature
Green J B JB Cook T L TL Smith J C JC Grainger R M RM
Proceedings of the National Academy of Sciences of the United States of America 19970801 16
The transforming growth factor beta superfamily member, activin, is able to induce mesodermal tissues in animal cap explants from Xenopus laevis blastula stage embryos. Activin can act like a morphogen of the dorsoventral axis in that lower doses induce more ventral, and higher doses more dorsal, tissue types. Activin has also previously been reported to induce neural tissues in animal caps. From cell mixing experiments it was inferred that this might be an indirect effect of induced mesoderm si ...[more]