Dataset Information

Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study.

ABSTRACT:

Objective

To evaluate the performance of low contrast media (CM) dose dual-energy computed tomography pulmonary angiography (CTPA) with advanced monoenergetic reconstructions in patients with suspected pulmonary embolism (PE).

Materials and methods

The study had institutional review board approval; all patients gave written informed consent. Forty-one patients (25 men, 16 women, mean age 62.9±14.7 years) undergoing low CM dose (15ml, 6g iodine) dual-energy CTPA with advanced monoenergetic reconstructions were matched via propensity-scoring based on logistic regression analysis with a comparison group of 41 patients (24 men, 17 women, mean age 62.7±13.9 years) undergoing standard CM dose single-energy CTPA (80ml, 24g iodine). Subjective (noise, artifacts) and objective (attenuation, noise, contrast-to-noise ratio (CNR)) image quality was assessed by two blinded, independent readers. All patients underwent clinical follow-up after three months for evaluation of adverse events.

Results

Interrater agreement for subjective image quality in both groups ranged from fair to excellent (ICC: 0.46-0.84); agreement for objective image quality was excellent (ICC: 0.83-0.93). There was no significant difference regarding subjective noise (p = 0.15-0.72) and artifacts (p = 0.16-1) between the low and the standard CM dose group. There was no significant difference regarding CNR between the CM dose groups (p = 0.11-0.87). Seven of the 41 (17%) patients in the low and 5/41 (12%) in the standard CM dose group were diagnosed with PE (p = 0.32). No patient suffered from subsequent PE or PE-associated death during the follow-up period.

Conclusion

Dual-energy CTPA with advanced monoenergetic reconstruction is feasible with 6g iodine and allows for the diagnosis and safe exclusion of central, lobar, and segmental PE.

SUBMITTER: Meier A

PROVIDER: S-EPMC5132396 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study.

Meier Andreas A Higashigaito Kai K Martini Katharina K Wurnig Moritz M Seifert Burkhardt B Keller Dagmar I DI Frauenfelder Thomas T Alkadhi Hatem H

PloS one 20161201 12

<h4>Objective</h4>To evaluate the performance of low contrast media (CM) dose dual-energy computed tomography pulmonary angiography (CTPA) with advanced monoenergetic reconstructions in patients with suspected pulmonary embolism (PE).<h4>Materials and methods</h4>The study had institutional review board approval; all patients gave written informed consent. Forty-one patients (25 men, 16 women, mean age 62.9±14.7 years) undergoing low CM dose (15ml, 6g iodine) dual-energy CTPA with advanced monoe ...[more]

PMID: 27907049

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Dataset Information

Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study.

Objective

Materials and methods

Results

Conclusion

Publications

Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study.

Similar Datasets

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