Unknown

Dataset Information

0

Paper-based CRP Monitoring Devices.


ABSTRACT: Here, we discuss the development of a paper-based diagnostic device that is inexpensive, portable, easy-to-use, robust, and capable of running simultaneous tests to monitor a relevant inflammatory protein for clinical diagnoses i.e. C-reactive protein (CRP). In this study, we first attempted to make a paper-based diagnostic device via the wax printing method, a process that was used in previous studies. This device has two distinct advantages: 1) reduced manufacturing and assay costs and operation duration via using wax printing method to define hydrophobic boundaries (for fluidic devices or general POC devices); and, 2) the hydrophilicity of filter paper, which is used to purify and chromatographically correct interference caused by whole blood components with a tiny amount of blood sample (only 5??L). Diagnosis was based on serum stain length retained inside the paper channels of our device. This is a balanced function between surface tension and chromatographic force following immune reactions (CRP assays) with a paper-embedded biomarker.

SUBMITTER: Lin SC 

PROVIDER: S-EPMC5133555 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


Here, we discuss the development of a paper-based diagnostic device that is inexpensive, portable, easy-to-use, robust, and capable of running simultaneous tests to monitor a relevant inflammatory protein for clinical diagnoses i.e. C-reactive protein (CRP). In this study, we first attempted to make a paper-based diagnostic device via the wax printing method, a process that was used in previous studies. This device has two distinct advantages: 1) reduced manufacturing and assay costs and operati  ...[more]

Similar Datasets

| S-EPMC5701284 | biostudies-literature
| S-EPMC3065124 | biostudies-literature
| S-EPMC6370803 | biostudies-other
| S-EPMC6030327 | biostudies-literature
| S-EPMC1959422 | biostudies-literature
| S-EPMC6327054 | biostudies-literature
| S-EPMC7450514 | biostudies-literature
| S-EPMC6209828 | biostudies-other
| S-EPMC4180781 | biostudies-literature
| S-EPMC7071557 | biostudies-literature